Ototoxicity

Ototoxicity is a side effect of a drug, for example, that is toxic to the cochlea or auditory nerve and sometimes to the vestibular system, especially to the ear. The effects of ototoxicity are reversible and temporary or irreversible and permanent. Ototoxic drugs include antibiotics such as gentamicin, streptomycin and tobramycin, loop diuretics such as furosemide, and platinum-based chemotherapy agents such as cisplatin, carboplatin and vincristine. Many non-steroidal anti-inflammatory drugs (NSAIDs) have also been shown to be ototoxic. This can lead to sensorineural hearing loss, dynamics or both. Some environmental and professional chemicals have also been shown to affect the auditory system and sound.

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